Although he shunned his usual practice of shaking hands and kissing babies as some 500 faithful filled a courtyard at the Apostolic Palace inside the Vatican.
At his second meeting since suspending general audiences on February 26, the crowd stood behind a barrier and some even lowered their masks to greet the leader of the Roman Catholic Church.
The pope shook hands with prelates attending the audience and, smiling, then turned to the crowd, persuading them not to shake hands and to return to their seats in order to “avoid contagion”.
Francis focused on the socio-economic impact of the pandemic which he said was “without barriers”.
He prescribed for a society in which people should have more solidarity with their neighbours.
Pope Francis, whose birth name is Jorge Bergoglio, has shown little fear for his health since the outbreak of the coronavirus pandemic early this year.
Before Wednesday he had never appeared with a mask and had continued to receive visitors within the Apostolic Palace — but they were fewer groups than before.
Last Thursday he shook hands with a group of French actors committed to defending the environment. The group was exempted from wearing face masks and included the actress Juliette Binoche.
The 83-year-old bishop found it difficult to wear a mask that restricted his breathing, a member of his entourage said Wednesday.
When he was 21 Jorge Bergoglio suffered from acute pleurisy and surgeons removed part of his right lung, according to his biographer Austen Ivereigh.
This forced him to give up his dream of becoming a Jesuit missionary in Japan and he also had to give up playing football.